Week 5 
Week 5 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 10/2 | 17:15 | SF | LAR | SoFi Stadium  | Prime | |
| Su | 10/5 | 6:30 | MIN | CLE | Tottenham Hotspur Stadium | NFL Net | |
| Su | 10/5 | 10:00 | HOU | BAL | M&T Bank Stadium | CBS | |
| Su | 10/5 | 10:00 | MIA | CAR | Bank of America Stadium | FOX | |
| Su | 10/5 | 10:00 | LV | IND | Lucas Oil Stadium | FOX | |
| Su | 10/5 | 10:00 | NYG | NO | Caesars Superdome | CBS | |
| Su | 10/5 | 10:00 | DAL | NYJ | MetLife Stadium | FOX | |
| Su | 10/5 | 10:00 | DEN | PHI | Lincoln Financial Field | CBS | |
| Su | 10/5 | 13:05 | TEN | ARI | State Farm Stadium | CBS | |
| Su | 10/5 | 13:05 | TB | SEA | Lumen Field | CBS | |
| Su | 10/5 | 13:25 | DET | CIN | Paycor Stadium | FOX | |
| Su | 10/5 | 13:25 | WAS | LAC | SoFi Stadium | FOX | |
| Su | 10/5 | 17:20 | NE | BUF | Highmark Stadium | NBC | |
| Mo | 10/6 | 17:15 | KC | JAX | EverBank Stadium | ABC | |