Week 5 
Week 5 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 10/8 | 17:15 | TB | DAL | AT&T Stadium  | Prime Video | |
| Su | 10/11 | 6:30 | PHI | JAX | Tottenham Hotspur Stadium | NFL Net | |
| Su | 10/11 | 10:00 | CHI | GB | Lambeau Field | FOX | |
| Su | 10/11 | 10:00 | CIN | MIA | Hard Rock Stadium | FOX | |
| Su | 10/11 | 10:00 | LV | NE | Gillette Stadium | CBS | |
| Su | 10/11 | 10:00 | MIN | NO | Caesars Superdome | FOX | |
| Su | 10/11 | 10:00 | CLE | NYJ | MetLife Stadium | CBS | |
| Su | 10/11 | 10:00 | IND | PIT | Acrisure Stadium | CBS | |
| Su | 10/11 | 10:00 | HOU | TEN | Nissan Stadium | CBS | |
| Su | 10/11 | 10:00 | NYG | WAS | Northwest Stadium | FOX | |
| Su | 10/11 | 13:05 | DEN | LAC | SoFi Stadium | CBS | |
| Su | 10/11 | 13:25 | DET | ARI | State Farm Stadium | FOX | |
| Su | 10/11 | 13:25 | SF | SEA | Lumen Field | FOX | |
| Su | 10/11 | 17:20 | BAL | ATL | Mercedes-Benz Stadium | NBC | |
| Mo | 10/12 | 17:15 | BUF | LAR | SoFi Stadium | ESPN | |