Week 4 
Week 4 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 10/1 | 17:15 | PIT | CLE | Huntington Bank Field  | Prime Video | |
| Su | 10/4 | 6:30 | IND | WAS | Tottenham Hotspur Stadium | NFL Net | |
| Su | 10/4 | 10:00 | TEN | BAL | M&T Bank Stadium | CBS | |
| Su | 10/4 | 10:00 | NE | BUF | New Highmark Stadium | CBS | |
| Su | 10/4 | 10:00 | NYJ | CHI | Soldier Field II | FOX | |
| Su | 10/4 | 10:00 | JAX | CIN | Paycor Stadium | CBS | |
| Su | 10/4 | 10:00 | DAL | HOU | NRG Stadium | FOX | |
| Su | 10/4 | 10:00 | ARI | NYG | MetLife Stadium | CBS | |
| Su | 10/4 | 10:00 | LAR | PHI | Lincoln Financial Field | FOX | |
| Su | 10/4 | 10:00 | GB | TB | Raymond James Stadium | FOX | |
| Su | 10/4 | 13:05 | MIA | MIN | U.S. Bank Stadium | FOX | |
| Su | 10/4 | 13:25 | DEN | SF | Levi's Stadium | CBS | |
| Su | 10/4 | 13:25 | LAC | SEA | Lumen Field | CBS | |
| Su | 10/4 | 13:25 | KC | LV | Allegiant Stadium | CBS | |
| Su | 10/4 | 17:20 | DET | CAR | Bank of America Stadium | NBC | |
| Mo | 10/5 | 17:15 | ATL | NO | Caesars Superdome | ESPN | |