Week 4 
Week 4 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 9/25 | 17:15 | SEA | ARI | State Farm Stadium  | Prime | |
| Su | 9/28 | 6:30 | MIN | PIT | Croke Park | NFL Net | |
| Su | 9/28 | 10:00 | WAS | ATL | Mercedes-Benz Stadium | CBS | |
| Su | 9/28 | 10:00 | NO | BUF | Highmark Stadium | CBS | |
| Su | 9/28 | 10:00 | CLE | DET | Ford Field | FOX | |
| Su | 9/28 | 10:00 | TEN | HOU | NRG Stadium | CBS | |
| Su | 9/28 | 10:00 | CAR | NE | Gillette Stadium | FOX | |
| Su | 9/28 | 10:00 | LAC | NYG | MetLife Stadium | CBS | |
| Su | 9/28 | 10:00 | PHI | TB | Raymond James Stadium | FOX | |
| Su | 9/28 | 13:05 | JAX | SF | Levi's Stadium | FOX | |
| Su | 9/28 | 13:05 | IND | LAR | SoFi Stadium | FOX | |
| Su | 9/28 | 13:25 | BAL | KC | GEHA Field at Arrowhead Stadium | CBS | |
| Su | 9/28 | 13:25 | CHI | LV | Allegiant Stadium | CBS | |
| Su | 9/28 | 17:20 | GB | DAL | AT&T Stadium | NBC | |
| Mo | 9/29 | 16:15 | NYJ | MIA | Hard Rock Stadium | ESPN | |
| Mo | 9/29 | 17:15 | CIN | DEN | Empower Field at Mile High | ABC | |