Week 2 
Week 2 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 9/17 | 17:15 | DET | BUF | New Highmark Stadium  | Prime Video | |
| Su | 9/20 | 10:00 | CAR | ATL | Mercedes-Benz Stadium | FOX | |
| Su | 9/20 | 10:00 | NO | BAL | M&T Bank Stadium | CBS | |
| Su | 9/20 | 10:00 | MIN | CHI | Soldier Field II | FOX | |
| Su | 9/20 | 10:00 | CIN | HOU | NRG Stadium | CBS | |
| Su | 9/20 | 10:00 | PIT | NE | Gillette Stadium | CBS | |
| Su | 9/20 | 10:00 | GB | NYJ | MetLife Stadium | FOX | |
| Su | 9/20 | 10:00 | CLE | TB | Raymond James Stadium | CBS | |
| Su | 9/20 | 10:00 | PHI | TEN | Nissan Stadium | FOX | |
| Su | 9/20 | 13:05 | JAX | DEN | Empower Field at Mile High | CBS | |
| Su | 9/20 | 13:05 | LV | LAC | SoFi Stadium | CBS | |
| Su | 9/20 | 13:25 | SEA | ARI | State Farm Stadium | FOX | |
| Su | 9/20 | 13:25 | WAS | DAL | AT&T Stadium | FOX | |
| Su | 9/20 | 13:25 | MIA | SF | Levi's Stadium | FOX | |
| Su | 9/20 | 17:20 | IND | KC | GEHA Field at Arrowhead Stadium | NBC | |
| Mo | 9/21 | 17:15 | NYG | LAR | SoFi Stadium | ESPN | |