Week 16 
Week 16 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 12/18 | 17:15 | LAR | SEA | Lumen Field  | Prime | |
| Sa | 12/20 | 14:00 | PHI | WAS | Northwest Stadium | FOX | |
| Sa | 12/20 | 17:20 | GB | CHI | Soldier Field II | FOX | |
| Su | 12/21 | 10:00 | TB | CAR | Bank of America Stadium | FOX | |
| Su | 12/21 | 10:00 | BUF | CLE | Huntington Bank Field | CBS | |
| Su | 12/21 | 10:00 | LAC | DAL | AT&T Stadium | FOX | |
| Su | 12/21 | 10:00 | CIN | MIA | Hard Rock Stadium | CBS | |
| Su | 12/21 | 10:00 | NYJ | NO | Caesars Superdome | CBS | |
| Su | 12/21 | 10:00 | MIN | NYG | MetLife Stadium | FOX | |
| Su | 12/21 | 10:00 | KC | TEN | Nissan Stadium | CBS | |
| Su | 12/21 | 13:05 | ATL | ARI | State Farm Stadium | FOX | |
| Su | 12/21 | 13:05 | JAX | DEN | Empower Field at Mile High | FOX | |
| Su | 12/21 | 13:25 | PIT | DET | Ford Field | CBS | |
| Su | 12/21 | 13:25 | LV | HOU | NRG Stadium | CBS | |
| Su | 12/21 | 17:20 | NE | BAL | M&T Bank Stadium | NBC | |
| Mo | 12/22 | 17:15 | SF | IND | Lucas Oil Stadium | ESPN | |