Week 12 
Week 12 | Start (PT) | Visitor | Home | Stadium | TV | |||
| Th | 11/20 | 17:15 | BUF | HOU | NRG Stadium  | Prime | |
| Su | 11/23 | 10:00 | NYJ | BAL | M&T Bank Stadium | CBS | |
| Su | 11/23 | 10:00 | PIT | CHI | Soldier Field II | CBS | |
| Su | 11/23 | 10:00 | NE | CIN | Paycor Stadium | CBS | |
| Su | 11/23 | 10:00 | NYG | DET | Ford Field | FOX | |
| Su | 11/23 | 10:00 | MIN | GB | Lambeau Field | FOX | |
| Su | 11/23 | 10:00 | IND | KC | GEHA Field at Arrowhead Stadium | CBS | |
| Su | 11/23 | 10:00 | SEA | TEN | Nissan Stadium | FOX | |
| Su | 11/23 | 13:05 | JAX | ARI | State Farm Stadium | CBS | |
| Su | 11/23 | 13:05 | CLE | LV | Allegiant Stadium | CBS | |
| Su | 11/23 | 13:25 | PHI | DAL | AT&T Stadium | FOX | |
| Su | 11/23 | 13:25 | ATL | NO | Caesars Superdome | FOX | |
| Su | 11/23 | 17:20 | TB | LAR | SoFi Stadium | NBC | |
| Mo | 11/24 | 17:15 | CAR | SF | Levi's Stadium | ESPN | |