| 2010 Week 1 Scores | |||||
| Game Time (PT) | Visitor | Home | |||
| Thursday, Sep 09 | Minnesota | - | New Orleans | ||
| Sunday, Sep 12 | Atlanta | - | Pittsburgh | ||
| Sunday, Sep 12 | Carolina | - | NY Giants | ||
| Sunday, Sep 12 | Cincinnati | - | New England | ||
| Sunday, Sep 12 | Cleveland | - | Tampa Bay | ||
| Sunday, Sep 12 | Denver | - | Jacksonville | ||
| Sunday, Sep 12 | Detroit | - | Chicago | ||
| Sunday, Sep 12 | Indianapolis | - | Houston | ||
| Sunday, Sep 12 | Miami | - | Buffalo | ||
| Sunday, Sep 12 | Oakland | - | Tennessee | ||
| Sunday, Sep 12 | Arizona | - | St Louis | ||
| Sunday, Sep 12 | Green Bay | - | Philadelphia | ||
| Sunday, Sep 12 | San Francisco | - | Seattle | ||
| Sunday, Sep 12 | Dallas | - | Washington | ||
| Monday, Sep 13 | Baltimore | - | NY Jets | ||
| Monday, Sep 13 | San Diego | - | Kansas City | ||